The Lock Pick Kit was used by Sam Fisher as a way to bypass locked doors. In the first Splinter Cell, doors could be opened using the standard lock picks, or a disposable lock pick. The ordinary lock picks are slow, but they are silent and can be used an infinite number of times, as opposed to the disposable lockpick which could only be used once and made a characteristic hissing noise. The player would use the joystick of the game controller to feel the vibration to successfully pick the pin. When successful, Sam will be able to unlock the door and silently enter the room.

In Chaos Theory, the disposable lock picks are replaced by Sam's SC Knife. The SC Knife is reusable, but creates even more noise than the disposable lock picks. In fact, the noise is about as loud as firing the SC-20K in a quiet environment.

Also in Chaos Theory, the player is provided with a telemetric lock pick for a bank robbery, which enables Sam to pick two locks simultaneously. This device is used to break into a vault.

In Double Agent, there is an advanced unlockable of the Lock Pick Kit: the Electrical Lock Pick Kit.